%0 Journal Article
%T A Study on MTHFR C677T Gene Polymorphism and Alcohol Dependence among Meiteis of Manipur, India
%A Huidrom Suraj Singh
%A Kabita Salam
%A Kallur Nava Saraswathy
%J Journal of Biomarkers
%D 2014
%I Hindawi Publishing Corporation
%R 10.1155/2014/310241
%X Chronic alcohol consumption is reported to be associated with increase in plasma homocysteine levels which is further influenced by the polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene. The present study aims to understand the extent of the MTHFR C677T polymorphism in alcohol dependent (AD) cases of Meiteis of Manipur, a Mendelian population of India. MTHFR C677T polymorphism was screened in 313 controls and 139 alcohol dependent (AD) cases who all met DSM-IV criteria for alcohol dependence. Both AD cases and controls were unrelated up to 1st cousin. Among the control group, different drinking patterns like abstainer/nondrinkers (NDs), occasional drinkers (ODs), and moderate drinkers (MDs) are included. Both the groups were found to be in Hardy-Weinberg equilibrium (). Genotypic and allelic frequency distribution of MTHFR C677T polymorphism did not differ significantly between AD cases and controls (). However, individuals carrying mutant (T) allele show more than 1-fold increased risk for AD though not significant (OR£¿=£¿1.43; 95% CI 0.41¨C5.01, ). In conclusion, MTHFR C677T polymorphism is not found to be risk marker for AD in present studied population. However, higher prevalence of the mutant T allele may exacerbate deleterious health risk in future especially among alcohol drinkers. 1. Introduction Alcoholism or alcohol dependence (AD) is a complex trait characterized by a cluster of physiological, behavioural, and cognitive phenomena in which the use of alcohol takes on a much higher priority for a given individual than other behaviours that once had greater value [1]. The World Health Organization (WHO) estimates that about 140 million people throughout the world suffer from AD [2]. Moreover, it is one of the leading health risks and is likely to become world¡¯s third largest risk factor for disease and disability. Approximately 2.5 million deaths each year are attributable to alcohol, resulting in 4% of all deaths worldwide [3]. Several studies show significance of genetic influences in substance abuse and dependence [4, 5]. However, comprehensive molecular and pathophysiological mechanism associated with AD is not completely revealed yet. As genetic predisposition to AD and its related morbidity and mortality is undebatable, the emerging research has picked up momentum targeting various pathways involved in alcohol consumption and metabolism for deeper understanding of the pathophysiology of AD. Recent studies revealed association of gene that encodes the methylenetetrahydrofolate reductase (MTHFR C677T) with AD. However, findings
%U http://www.hindawi.com/journals/jbm/2014/310241/