%0 Journal Article
%T Regulation of KCa2.3 and endothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes
%A Kathryn M. Gauthier
%A William B. Campbell
%A Alister J. McNeish
%J PeerJ
%D 2015
%I 
%R 10.7717/peerj.414
%X Background and Purpose. In rat middle cerebral arteries, endothelium-dependent hyperpolarization (EDH) is mediated by activation of calcium-activated potassium (KCa) channels specifically KCa2.3 and KCa3.1. Lipoxygenase (LOX) products function as endothelium-derived hyperpolarizing factors (EDHFs) in rabbit arteries by stimulating KCa2.3. We investigated if LOX products contribute to EDH in rat cerebral arteries.
%K Endothelium
%K Lipoxygensase
%K Isoprostane
%K Calcium-activated potassium channels
%K Nitric oxide
%K EDH
%K EDHF
%K Cerebral artery
%K Vasodilation
%K Arachidonic acid
%U https://peerj.com/articles/414/