%0 Journal Article
%T Increased Circulating Levels of Vitamin D Binding Protein in MS Patients
%A Arturo Ottavio Rinaldi
%A Isabella Sanseverino
%A Cristina Purificato
%A Antonio Cortese
%A Rosella Mechelli
%A Silvia Francisci
%A Marco Salvetti
%A Enrico Millefiorini
%A Sandra Gessani
%A Maria Cristina Gauzzi
%J Toxins
%P 129-137
%D 2015
%I MDPI AG
%R 10.3390/toxins7010129
%X Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS.
%K vitamin D binding protein
%K albumin
%K relapsing/remitting multiple sclerosis
%K beta-interferon
%K immunology
%K vitamin D
%U http://www.mdpi.com/2072-6651/7/1/129