%0 Journal Article
%T Bacteriophage-Derived Vectors for Targeted Cancer Gene Therapy
%A Md Zahidul Islam Pranjol
%A Amin Hajitou
%J Viruses
%P 268-284
%D 2015
%I MDPI AG
%R 10.3390/v7010268
%X Cancer gene therapy expanded and reached its pinnacle in research in the last decade. Both viral and non-viral vectors have entered clinical trials, and significant successes have been achieved. However, a systemic administration of a vector, illustrating safe, efficient, and targeted gene delivery to solid tumors has proven to be a major challenge. In this review, we summarize the current progress and challenges in the targeted gene therapy of cancer. Moreover, we highlight the recent developments of bacteriophage-derived vectors and their contributions in targeting cancer with therapeutic genes following systemic administration.
%K bacteriophage
%K CMV
%K Grp78
%K AAVP
%K HSVtk
%K RGD4C-AAVP/CMV-HSVtk
%K RGD4C-AAVP/Grp78-HSVtk
%K glioblastoma
%U http://www.mdpi.com/1999-4915/7/1/268