%0 Journal Article
%T Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin
%A Jixue Wang
%A Weiguo Xu
%A Jianxun Ding
%A Shengfan Lu
%A Xiaoqing Wang
%A Chunxi Wang
%A Xuesi Chen
%J Materials
%P 216-230
%D 2015
%I MDPI AG
%R 10.3390/ma8010216
%X Nanoscale micelles as an effective drug delivery system have attracted increasing interest in malignancy therapy. The present study reported the construction of the cholesterol-enhanced doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (CDM/DOX), poly(L-lactide)-based micelle (CLM/DOX), and stereocomplex micelle (CSCM/DOX) from the equimolar enantiomeric 4-armed poly(ethylene glycol)¨Cpolylactide copolymers in aqueous condition. Compared with CDM/DOX and CLM/DOX, CSCM/DOX showed the smallest hydrodynamic size of 96 ¡À 4.8 nm and the slowest DOX release. The DOX-loaded micelles exhibited a weaker DOX fluorescence inside mouse renal carcinoma cells ( i.e., RenCa cells) compared to free DOX¡¤HCl, probably because of a slower DOX release. More importantly, all the DOX-loaded micelles, especially CSCM/DOX, exhibited the excellent antiproliferative efficacy that was equal to or even better than free DOX¡¤HCl toward RenCa cells attributed to their successful internalization. Furthermore, all of the DOX-loaded micelles exhibited the satisfactory hemocompatibility compared to free DOX¡¤HCl, indicating the great potential for systemic chemotherapy through intravenous injection.
%K cholesterol
%K controlled delivery
%K doxorubicin
%K malignancy therapeutics
%K polylactide
%K stereocomplex micelle
%U http://www.mdpi.com/1996-1944/8/1/216