%0 Journal Article
%T Sulfadiazine¡ªChitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds
%A Raluca Petronela Dumitriu
%A Lenuta Profire
%A Loredana Elena Nita
%A Oana Maria Dragostin
%A Nicolae Ghetu
%A Drago Pieptu
%A Cornelia Vasile
%J Materials
%P 317-338
%D 2015
%I MDPI AG
%R 10.3390/ma8010317
%X In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform¡ªInfrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and in vitro sulfadiazine release were also investigated. The antimicrobial activity was evaluated towards three bacterial strains: Escherichia coli, Listeria monocytogenes and Salmonella thyphymurium. The developed PECs demonstrated their antimicrobial efficiency against tested bacterial strains, the PECs containing sulfadiazine-modified chitosan being more active than PECs containing unmodified chitosan.
%K chitosan
%K hyaluronic acid
%K sulfadiazine
%K polyelectrolyte complex
%K burn wound
%U http://www.mdpi.com/1996-1944/8/1/317