%0 Journal Article
%T Lipid Extract from Hard-Shelled Mussel (Mytilus coruscus) Improves Clinical Conditions of Patients with Rheumatoid Arthritis: A Randomized Controlled Trial
%A Yuanqing Fu
%A Guipu Li
%A Xinhua Zhang
%A Gengyan Xing
%A Xiaojie Hu
%A Lifeng Yang
%A Duo Li
%J Nutrients
%P 625-645
%D 2015
%I MDPI AG
%R 10.3390/nu7010625
%X Studies have suggested a lipid extract from hard-shelled mussel ( Mytilus coruscus) (HMLE) possessed strong anti-inflammatory activity in arthritis model of rats. This study investigated whether HMLE could improve clinical conditions of rheumatoid arthritis patients. Fifty rheumatoid arthritis patients (28¨C75 years) were randomly assigned to receive HMLE capsules or receive placebo capsules for 6 months. Forty-two subjects and 50 subjects were included in per-protocol and intention-to-treat analysis, respectively. Significant differences in changes on disease activity score (DAS28) and clinical disease activity index (CDAI) after 6-month intervention ( p < 0.01) were observed in both analyses with more evident efficacy shown in per-protocol population (£¿DAS28 = 0.47; £¿CDAI = 4.17), which favored the benefits of the HMLE group. TNF-¦Á (tumor necrosis factor ¦Á), interleukin (IL)-1¦Â and PGE 2 (prostaglandin E2) but not IL-6, were significantly decreased in both groups, and the decrements were much larger in the HMLE group for TNF-¦Á and PGE 2 after 6 months from baseline ( p < 0.05). IL-10 was significantly increased in both groups and the change was much more evident in the HMLE group ( p < 0.05). In conclusion, HMLE exhibited benefits for the clinical conditions of rheumatoid patients in relation to improvement in the balance between pro- and anti-inflammatory factors, which indicated its potential to serve as adjunctive treatment for rheumatoid arthritis. (ClinicalTrials.gov NCT02173587).
%K anti-inflammation
%K clinical conditions
%K hard-shelled mussel
%K lipid extract
%K rheumatoid arthritis
%U http://www.mdpi.com/2072-6643/7/1/625