%0 Journal Article
%T Indoor and Outdoor Exposure to Ultrafine, Fine and Microbiologically Derived Particulate Matter Related to Cardiovascular and Respiratory Effects in a Panel of Elderly Urban Citizens
%A Dorina Gabriela Karottki
%A Michal Spilak
%A Marie Frederiksen
%A Zorana Jovanovic Andersen
%A Anne Mette Madsen
%A Matthias Ketzel
%A Andreas Massling
%A Lars Gunnarsen
%A Peter Mller
%A Steffen Loft
%J International Journal of Environmental Research and Public Health
%P 1667-1686
%D 2015
%I MDPI AG
%R 10.3390/ijerph120201667
%X To explore associations of exposure to ambient and indoor air particulate and bio-aerosol pollutants with cardiovascular and respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home air filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) and surfactant protein-D (SPD) were examined in relation to exposure preceding each measurement. Exposure assessment included 48-h urban background monitoring of PM 10, PM 2.5 and particle number concentration (PNC), weekly measurements of PM 2.5 in living- and bedroom, 24-h measurements of indoor PNC three times, and bio-aerosol components in settled dust on a 2-week basis. Statistically significant inverse associations included: MVF with outdoor PNC; granulocyte counts with PM 2.5; CD31 expression with dust fungi; SPD with dust endotoxin. Significant positive associations included: MVF with dust bacteria; monocyte expression of CD11 with PM 2.5 in the bedroom and dust bacteria and endotoxin, CD31 expression with dust serine protease; serum CC16 with dust NAGase. Multiple comparisons demand cautious interpretation of results, which suggest that outdoor PNC have adverse effects on MVF, and outdoor and indoor PM 2.5 and bio-aerosols are associated with markers of inflammation and lung cell integrity.
%K ultrafine particles
%K indoor air pollution
%K ambient air pollution
%K PM2.5
%K bioaerosols
%K microvascular function
%K lung function
%K inflammation
%U http://www.mdpi.com/1660-4601/12/2/1667