%0 Journal Article
%T Synthesis of a Temperature-Sensitive Matrine-Imprinted Polymer and Its Potential Application for the Selective Extraction of Matrine from Radix Sophorae Tonkinensis
%A Minjie Jiang
%A Lisheng Wang
%A Xu Liu
%A Hua Yang
%A Fan Ren
%A Lizhen Gan
%A Weizhe Jiang
%J International Journal of Molecular Sciences
%P 3441-3451
%D 2015
%I MDPI AG
%R 10.3390/ijms16023441
%X A temperature-sensitive matrine-imprinted polymer was prepared in chloroform by free-radical cross-linking copolymerization of methacrylic acid at 60 ˇăC in the presence of ethylene glycol dimethacrylate as the cross-linker, N-isopropyl acrylamide as the temperature-responsive monomer and matrine as the template molecule. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on molecular imprinted polymer (MIP) at 50 ˇăC. Additionally, the thermoresponsive MIP was tested for its application as a sorbent material for the selective separation of matrine from Chinese medicinal plant radix Sophorae tonkinensis. It was shown that the thermoresponsive MIP displayed different efficiency in clean-up and enrichments using the SPE protocol at different temperatures.
%K molecularly imprinted polymer
%K N-isopropyl acrylamide
%K matrine
%K ultrasonic extraction
%U http://www.mdpi.com/1422-0067/16/2/3441