%0 Journal Article
%T Interleukin-27 in T Cell Immunity
%A Yukiko Iwasaki
%A Keishi Fujio
%A Tomohisa Okamura
%A Kazuhiko Yamamoto
%J International Journal of Molecular Sciences
%P 2851-2863
%D 2015
%I MDPI AG
%R 10.3390/ijms16022851
%X Interleukin (IL)-27, a member of IL-12/IL-23 heterodimeric family of cytokines, has pleiotropic properties that can enhance or limit immune responses. IL-27 acts on various cell types, including T cells, B cells, macrophages, dendritic cells, natural killer (NK) cells and non-hematopoietic cells. Intensive studies have been conducted especially on T cells, revealing that various subsets of T cells respond uniquely to IL-27. IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway. On the other hand, IL-27 suppresses immune responses through inhibition of the development of T helper (Th) 17 cells and induction of IL-10 production in a STAT1- and STAT3-dependent manner. IL-27 is a potentially promising cytokine for therapeutic approaches on various human diseases. Here, we provide an overview of the biology of IL-27 related to T cell subsets, its structure, and production mechanism.
%K IL-27
%K IL-27p28
%K Ebi3
%K T cell subset
%U http://www.mdpi.com/1422-0067/16/2/2851