%0 Journal Article
%T Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
%A Jingxiao Zhang
%A Yan Li
%A Su-Shing Chen
%A Lilei Zhang
%A Jinghui Wang
%A Yinfeng Yang
%A Shuwei Zhang
%A Yanqiu Pan
%A Yonghua Wang
%A Ling Yang
%J International Journal of Molecular Sciences
%P 2913-2941
%D 2015
%I MDPI AG
%R 10.3390/ijms16022913
%X Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-¦ĘB signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
%K systems pharmacology
%K herbal medicine
%K anti-inflammation
%K Folium Eriobotryae
%U http://www.mdpi.com/1422-0067/16/2/2913