%0 Journal Article
%T Interleukin-1 involved in Apoptosis of Beta-Thalassemia/Hemoglobin E Erythroid Progenitor Cells
%A Umesh Prasad Gupta
%A Pranee Fucharoen
%A Dalina I Tanyong
%J Asian Journal of Medical Sciences
%P 8-14
%D 2012
%I Asian Journal of Medical Sciences Pokhara
%R 10.3126/ajms.v3i4.6805
%X Objective: The major pathophysiological features of ¦Â-thalassemia are anemia and ineffective erythropoiesis. Ineffective erythropoiesis has been shown by an intense marrow erythroid hyperplasia and increased apoptosis during basophilic to orthochromatic normoblast stages. Some cytokines like interferon-¦Ã (IFN-¦Ã), tumor necrosis factor ¦Á (TNF-¦Á) and interleukin-1 (IL-1) have been found to involved in apoptosis. Although the pro-apoptotic activity of IFN-¦Ã and TNF-¦Á is well documented, there are only few studies on IL-1, especially on erythroid lineage. In this in vitro study, the role of cytokine IL-1¦Á and IL-1¦Â in apoptosis of erythroid progenitor cells from ¦Â- thalassemia/HbE patients was assessed.
%K Ineffective erythropoiesis
%K apoptosis
%K IL-1
%K beta-thalassemia
%K HbE
%U http://nepjol.info/index.php/AJMS/article/view/6805