%0 Journal Article
%T Nuclear Factor-Kappa B and Other Oxidative Stress Biomarkers in Serum of Autistic Children
%A Omar M. E. Abdel-Salam
%A Eman R. Youness
%A Nadia A. Mohammed
%A Walaa A. Abu Elhamed
%J Open Journal of Molecular and Integrative Physiology
%P 18-27
%@ 2162-2167
%D 2015
%I Scientific Research Publishing
%R 10.4236/ojmip.2015.51002
%X The aim of the present study was to investigate the status of oxidative stress in the serum of children affected with autism spectrum disorder. Twenty autistic children aged 3 to 12 years, were gender and age-matched with 20 typically developing children. Changes in the levels of the redox-sensing transcription factor nuclear factor-kappa B (NF-<i>¦Ê</i>B) was measured in serum of autistic children and controls. Other oxidative stress biomarkers such as malondialdehyde, reduced glutathione, total antioxidant capacity, catalase activity, and paraoxonase 1 activity were determined in serum as well. Significant increase was observed in serum NF-<i>¦Ê</i>B of autistic children compared to that in controls (by 138.6%). There was also marked increase in malondialdehyde level by 87.3% in autistic patients. Meanwhile, there were significant decreases in reduced glutathione (by 24%), catalase activity (by 40.8%), paraoxonase 1 activity (by 36.6%), and total antioxidant capacity (by 36.5%) compared to the control group. These data clearly demonstrate increased oxidative stress in serum of autistic children and suggest that the NF-<i>¦Ê</i>B signaling pathway is activated in autism, possibly due to increased oxidative burden.
%K Autism Spectrum Disorder
%K Oxidative Stress
%K Redox-Sensing Transcription Factor
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=54157