%0 Journal Article
%T Synthesis and Bioactivity of Natural Occurring Petasin-Like Derivatives as Antitumor Agents
%A Xiaolong Shi
%A Saiyang Zhang
%A Jianghao Wang
%A Tingyu Li
%A Junju Liu
%A Yi Hou
%A Lei Liu
%A Dongjun Fu
%A Haiwei Xu
%A Hongmin Hongmin
%A Yanbing Zhang
%J Open Journal of Medicinal Chemistry
%P 23-31
%@ 2164-313X
%D 2015
%I Scientific Research Publishing
%R 10.4236/ojmc.2015.52003
%X Petasin is a potential antitumor against human neuroblastoma cell SK-N-SH by inhibiting the ERK1/2 phosphorylation. In view of its great activity and new antiproliferative mechanisms, a series of petasin derivatives were designed and synthesized, which showed great antiproliferative activity. Among them compounds 1h and 1f were more effective against SK-N-SH cells than petasin with the IC<sub>50</sub> values of 0.87 and 2.63 ¦ÌM, respectively.
%K Petasin
%K SK-N-SH
%K Mechanism
%K Derivative
%K Antiproliferative Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=56965