%0 Journal Article
%T 4-硫胸苷的合成新方法
New Method for the Synthesis of 4-Thiothymidine
%A 闫德峰
%A 赫玲爽
%A 马克东
%A 张晓辉
%A 李德鹏
%J Studies in Synthetic Chemistry
%P 70-73
%@ 2332-7960
%D 2015
%I Hans Publishing
%R 10.12677/SSC.2015.33011
%X
4-硫胸苷/UVA(长波黑斑效应紫外线)辅助疗法为癌症治疗提供了新的途径,通过对胸苷进行修饰,得到对近紫外光敏感的药物,从而在紫外光的协同作用下达到治疗肿瘤细胞的作用。为了得到新型具有光学性质的4-硫胸苷类药物,传统使用三唑法和P2S5法,而本文采用了新试剂——Lawesson试剂,极大的缩短了反应时间,提高了产率,并用1H-NMR及13C-NMR表征了产物结构。
4-Thiothymidine combined with UVA (light shading effect with long-wave ultraviolet) as a potentially novel therapy for cancer provides a new way, UVA-sensitive 4-thiothymidine was obtained through the study of the modification of thiothymidine at 4-position, and reached the role of treatment of tumor cells under the synergy of UVA. In order to obtain 4-Thiothymidine drugs with new optical properties, triazole and P2S5 are used in previously reported methods. In this study, Lawesson reagent was adopted to prepare 4-thiothymidine. Under the optimized conditions, the reaction time was significantly reduced and the yield increased. The structure of the product was characterized by 1H-NMR and 13C-NMR.
%K 4-硫胸苷,Lawesson试剂,合成,抗肿瘤活性
4-Thiothymidine
%K Lawesson Reagent
%K Synthesis
%K Antitumor Activity
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=16039