%0 Journal Article
%T EffectsofsenescenceontheexpressionofBDNFandTrkBreceptorinthelateralgeniculatenucleusofcats
%A Chuan-Wang TONG
%A Zi-Lu WANG
%A Peng LI
%A Hui ZHU
%A Cui-Yun CHEN
%A Tian-Miao HUA
%J 动物学研究
%P 48-53
%D 2015
%R 10.13918/j.issn.2095-8137.2015.1.48
%X Toexploretheneuralmechanismsmediatingaging-relatedvisualfunctiondeclines,wecomparedtheexpressionsofbrain-derivedneurotrophicfactor(BDNF)anditshighaffinityreceptor-tyrosinekinaseB(TrkB)betweenyoungandoldadultcats.Nisslstainingwasusedtodisplayneuronsineachlayerofthelateralgeniculatenucleus(LGN).TheBDNF-andTrkBreceptor-immunoreactiveneuronswerelabeledimmunohistochemically,observedunderopticalmicroscopeandphotographed.Theirneuronaldensityandimmunoreactiveintensityweremeasured.ResultsshowedthatthemeandensityoftheNisslstainedneuronsineachLGNlayerwerecomparablebetweenoldandyoungadultcats,andtheirBDNFandTrkBproteinswerewidelyexpressedinallLGNlayers.However,comparedwithyoungadultcats,boththedensityandopticalabsorbanceintensityofBDNF-andTrkB-immunoreactivecellsineachLGNlayerinoldcatsweresignificantlydecreased.ThesefindingsindicatethatthedecreasedexpressionsofBDNFandTrkBproteinsintheLGNmaybeanimportantfactorinducingthecompromisedinhibitioninthecentralvisualnucleusandthefunctionalvisualdeclineinsenescentindividuals.
%K Cat
%K Lateralgeniculatenucleus
%K BDNF
%K TrkB
%K Age-relatedchange
%U http://www.zoores.ac.cn/CN/abstract/abstract3562.shtml