%0 Journal Article
%T Psychophysiological Effects of <i>Sideritis</i> and <i>Bacopa</i> Extract and Three Combinations Thereof¡ªA Quantitative EEG Study in Subjects Suffering from Mild Cognitive Impairment (MCI)
%A Wilfried Dimpfel
%A Leonie Schombert
%A Andreas Biller
%J Advances in Alzheimer's Disease
%P 1-22
%@ 2169-2467
%D 2016
%I Scientific Research Publishing
%R 10.4236/aad.2016.51001
%X Mild cognitive impairment (MCI) is regarded as a transitional stage during the development of Alzheimer¡¯s disease. Diagnosis of MCI can be obtained by the questionnaire ¡°DemTect¡± in German speaking countries. Quantitative assessment has been successfully performed using psychometric testing concomitantly with quantitative EEG recording. The present investigation aimed at the possible treatment of MCI with two botanicals, namely extracts from <i>Sideritis scardica</i> (500 mg) or <i>Bacopa monnieri</i> (320 mg) and three combinations thereof using this method in order to find a new treatment. The performance of the d2-test, an arithmetic calculation test (CPT) and a memory-test revealed better performance for the d2-test only in the presence of <i>Sideritis</i> extract or the combinations with <i>Bacopa</i> extract. Quantitative EEG assessment during the different experimental conditions showed massive differences between both extracts. Whereas <i>Sideritis</i> extract and its combination with a low amount of <i>Bacopa</i> extract (160 mg) induced increases of spectral power in fronto-temporal brain areas, <i>Bacopa</i> and the combination of <i>Sideritis</i> with high amounts of <i>Bacopa</i> extract produced attenuation of all waves except for delta in fronto-temporal brain areas. These differences were also documented by quantitative EEG maps in comparison to Placebo. A different action of both extracts was confirmed by discriminant analysis, where <i>Sideritis</i> extract and its combination with low <i>Bacopa</i> grouped together quite at distance to <i>Bacopa</i> and the combination of <i>Sideritis</i> with high <i>Bacopa</i>. A combination of <i>Sideritis</i> extract with a low amount of <i>Bacopa</i> should be tested with daily repetitive dosing for at least 4 weeks as a consequence.
%K DemTect
%K Cognition
%K Psychometry
%K EEG
%K Source density
%K Mild Cognitive Impairment (MCI)
%K Alzheimer¡¯s Disease
%K CATEEM
%K &lt
%K i&gt
%K Sideritis&lt
%K /i&gt
%K &lt
%K i&gt
%K Bacopa&lt
%K /i&gt
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=64876