%0 Journal Article
%T Diphenhydramine Compact-Cell Sensor
%A Mohsen M. Zareh
%A Mohammed I. ALahmdi
%A Ali A. Keshk
%J Journal of Sensor Technology
%P 1-10
%@ 2161-1238
%D 2016
%I Scientific Research Publishing
%R 10.4236/jst.2016.61001
%X The construction and performance characteristics of a novel (diphenhydramine) DPH CC-sensor
based on DZCE were reported in this work. The CC-membrane was prepared by incorporating of
(diazacrown ether) DZCE and/or (tetraflorophenyl borate) TFPB into a plasticized poly(vinyl
chloride) membrane. The CC-sensor revealed a Nernstian behavior over a DPH-concentration
range (9.1 ¡Á 10<sup>-3</sup> - 6.3 ¡Á 10<sup>-7</sup> mol	¡¤L<sup>-1</sup>), and relatively low detection limit (1 ¡Á 10<sup>-7</sup> mol	¡¤L<sup>-1</sup>). The potentiometric
response was independent on the pH of the solution in the range of 7 - 10. The
DPH-CC showed a very short response time (&lt;5 s). It showed good selectivity towards different cations
and pharmaceutical compounds. The relative selectivity coefficient was applied for evaluation
of the selectivity properties of the DPH-CC. The DPH-CC was used successfully for determination
of DPH in its samples. The found recovery range was 95% - 98.5%, and the standard deviation
value ranged between 0.13 - 0.42. The DPH-CC facilitates the analysis of DPH directly without pretreatment
and it can be built-in as a detector in chromatographic apparatus. It can be used as a
tool for on-line monitoring of the drug levels.
%K Compact Cell
%K Diphenhydramine Determination
%K Drug Sensor
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=65266