%0 Journal Article
%T Adipocyte Derived Mesenchymal Stromal Cell and Platelet Lysate: Ideal Cell and  Supplement for the Treatment of  Immune-Inflammatory Diseases?
%A Felipe Rodrigues
%A Annelise Pezzi
%A ¨¢lvaro Laureano
%A Vanessa Valim
%A Bruna Zambonato
%A Alice Dahmer
%A Let¨ªcia Baggio
%A Filipe Sehn
%A Iana¨º Wilke
%A Maria Aparecida L. da Silva
%A Bruna Amorin
%J CellBio
%P 15-25
%@ 2325-7792
%D 2016
%I Scientific Research Publishing
%R 10.4236/cellbio.2016.52002
%X Background: Mesenchymal stromal cells (MSC) are being tested for the treatment of immune diseases. MSC are present in several adult tissues which milieu may influence MSC behavior particularly under inflammatory conditions. Additionally, culture conditions also can modify cell function or state of activation. Methods: To address the influence of the MSC source on its characteristics, we studied a xenofree, platelet lysate supplemented MSC from dental pulp, adipose tissue and bone marrow, co-cultured with isolated T cells and PBMC subset, and studied the effect of culture animal or human supplements immunomodulatory effect. Results: All three sources were efficient in inhibiting T cells. Among all MSC sources, as also described by others, adipose MSC was capable to significantly induce Treg phenotype and decrease T CD8+. Furthermore, comparing fetal bovine serum and platelet lysate, results demonstrate that platelet lysate alone is capable to induce immunomodulatory phenotype. Additional studies have to be made to elucidate the PL immunomodulatory effect.
%K Mesenchymal Stromal Cells
%K Dental Pulp
%K Adipose Tissue
%K Bone Marrow
%K T Cells Immunomodulatory Effect
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=67077