%0 Journal Article
%T Liposarcomas of the hypopharynx: a systematic review of the literature
%A "Andrea Corvino"
%A "Giuseppe Riva"
%A "Matteo Sensini"
%A "Massimiliano Garzaro"
%A "Giancarlo Pecorari"
%J Journal of Health and Social Sciences
%P 57-66
%@ 2499-5886
%D 3
%R 10.19204/2016/lpsr8
%X Introduction: Liposarcomas are considered the most common type of soft tissue sarcoma in adults.
They represent approximately 20% of all mesenchymal malignancies and most frequently involve
the retroperitoneum, trunk and extremities. Hypopharyngeal localisation of a liposarcoma is extremely
rare. To determine the prevalence of liposarcomas of the hypopharynx, we conducted a
systematic review of the literature.
Methods: We performed a systematic search of the literature until 2015 using PubMed and Ovid.
The search identified 28 cases of hypopharyngeal liposarcomas. The inclusion criteria were: clinical
trials, cohort studies, case-control studies, case reports and case series on hypopharyngeal liposarcomas.
From an initial 77 articles, 23 articles were selected for this systematic review. The natural
history, imaging features, histology, treatment and prognosis were analysed.
Results: The incidence peaked in the sixth and seventh decades. Diagnostic procedures were based
on the barium swallow test, endoscopic examinations, and computed tomography (CT)/magnetic
resonance (MR) imaging. A well-differentiated liposarcoma represented the most frequent histological
subtype. Surgical excision was the main treatment. Endoscopic resection appeared to
be useful for peduncolated tumours of the hypopharynx. The 1-year disease-free survival rate was
89.47%.
Conclusions: A hypopharyngeal liposarcoma is a rare pathology, but it should kept in mind when a
mass of the hypopharynx is discovered. A cervical approach is better, irrespective of the size of the
tumour, except for cases in which an endoscopic approach is feasible. Local recurrence is common.
Therefore, patients should undergo regular examinations, at least for up to 5 years.
%K "liposarcoma"
%K "hypopharyngeal neoplasms"
%K "hypopharynx"
%K "piriform sinus"
%K "lateral pharyngotomy"
%K "systematic review"
%U http://journalhss.com/wp-content/uploads/JHHS1157-66.pdf