%0 Journal Article
%T Prognostic Significance of Pigment Epithelium-Derived Factor Expression in Patients with Non-Small-Cell-Lung Cancer
%A Alexander Emmert
%A Angelika Oellerich
%A Laszlo F¨¹zesi
%A Regina Waldmann-Beushausen
%A Friedrich A. Sch£¿ndube
%A Hanibal Bohnenberger
%A Bernhard C. Danner
%J Advances in Lung Cancer
%P 30-38
%@ 2169-2726
%D 2016
%I Scientific Research Publishing
%R 10.4236/alc.2016.53004
%X The
aims of this study were to examine prognostic significance of pigment epithelium-derived
factor (PEDF) in patients with stage IA-IIIB non-small cell lung cancer (NSCLC).
Using immunohistochemistry and multivariate analysis<span style=\"font-family:Verdana;\">,</span><span style=\"font-family:Verdana;\"> we set out to investigate whether PEDF expression
could provide prognostic information in NSCLC in a cohort of 69 patients who
had undergone radical resection for NSCLC. The correlation between PEDF and the
clinical pathological features of stage I-III NSCLC after radical surgery were
analyzed</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">as well as
influence on long term survival. No correlation between PEDF intensity, PEDF
area or PEDF area index and clinic</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">opathologic
parameters was seen. PEDF values showed a slight correlation to the tumor
stage. There was a significant negative correlation (T</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-0.288, p</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">0.002)
between pathologic T-stage and median PEDF area and vice versa a positive
correlation (T</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">0.227, p</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">=</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">0.016) with median PEDF intensity. We could not
detect any correlation between PEDF and long term survival. For PEDF analysis</span><span style=\"font-family:Verdana;\">,</span><span style=\"font-family:Verdana;\"> there was only a slight correlation between expression
and T-stage of the tumor.</span>
%K NSCLC
%K PEDF
%K Neoangiogenesis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=70795