%0 Journal Article
%T Synthesis and Anti-Cancer Activities of Resveratrol Derivatives
%A Xing Zheng
%A Liuying Yu
%A Xu Yao
%A Bo Lv
%A Zehua Yang
%A Qutong Zheng
%A Haiying Duan
%A Chen Song
%A Hailong Xie
%J Open Journal of Medicinal Chemistry
%P 51-57
%@ 2164-313X
%D 2016
%I Scientific Research Publishing
%R 10.4236/ojmc.2016.63005
%X A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ¡À 1.02 ¦ÌM, 122.68.27 ¡À 2.04 ¦ÌM, compared to that IC50 value of 5-FU is 98.59¡À3.61 ¦ÌM,156.74¡À6.16 ¦ÌM, respectively.
%K Resveratrol Derivatives
%K Wittig-Horner Reaction
%K MTT Method
%K Breast Carcinoma
%K Gastric Carcinoma
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=71080