%0 Journal Article
%T A Simple and ¡°Green¡± Method for Synthesis of Magnetic Hollow Silica Spheres and Its <sup>99</sup>Tc<sup>m</sup> Labeled Targeting Studies
%A Yicheng Liu
%A Xiazhang Li
%A Jen Sloppy
%A Yan Huang
%A Pingping Yao
%A Junya Yang
%A Yuxiang Yang
%J Open Journal of Inorganic Chemistry
%P 1-15
%@ 2161-7414
%D 2017
%I Scientific Research Publishing
%R 10.4236/ojic.2017.71001
%X The magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were prepared by a simple and ¡°green¡± method using functionalized SiO<sub>2</sub> spheres as templates. Magnetic particles (Fe<sub>3</sub>O<sub>4</sub>) were deposited on the SiO<sub>2</sub> surface by varying the molar ratio of [Fe<sup>2+</sup>]/[Fe<sup>3+</sup>] and the molar concentration of iron salts. The obtained magnetic hollow silica spheres exhibited a super-paramagnetic behavior at room temperature. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray powder scattering (XRD) were applied to characterize the MHSS. Besides, their unit cell parameters are calculated according to results indexing to XRD, the MHSS sample prepared at 0.10 M iron salts and 2:1 molar ratio of [Fe<sup>2+</sup>]/[Fe<sup>3+</sup>] has a largest cell angle (<span style=\"white-space:nowrap;\"><em>¦Â</em></span>) of unit cell. Due to large hollow cavity space and super-paramagnetic characteristics, the inner amino-functionalized MHSS could be labeled with radioisotope <sup>99</sup>Tc<sup>m</sup> to study the MHSS¡¯s magnetic targeting distribution<em> in vivo</em>. These results indicate that the MHSS has potential in the magnetic targeted drug delivery system which reduces the damage to normal cells and improves the therapeutic effect of cancer.
%K A Simple and ¡°Green¡± Method
%K Magnetic Hollow Silica Spheres
%K Magnetic Targeting
%K Iron Salts
%K Radioisotope &lt
%K sup&gt
%K 99&lt
%K /sup&gt
%K Tc&lt
%K sup&gt
%K m&lt
%K /sup&gt
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=72973