%0 Journal Article
%T Fitting Nonlinear Calibration Curves: No Models Perfect
%A Julia Martin
%A Alberto Romero Gracia
%A Agust¨ªn G. Asuero
%J Journal of Analytical Sciences, Methods and Instrumentation
%P 1-17
%@ 2164-2753
%D 2017
%I Scientific Research Publishing
%R 10.4236/jasmi.2017.71001
%X The study of the calibration of a series of compounds of environmental concern (six perfluoroalkyl compounds (perfluorooctane sulfonic acid and five perfluoroalkyl carboxylic acids), three preservatives (methyl-, ethyl- and propylparabens) and the brominated flame retardant hexabromocyclododecane) by LC-MS/MS has been carries out, with a view to their simultaneous determination in samples of environmental interest. In some cases nonlinear calibration curves are obtained, but restricting the concentration range a linear model may be used to fit the data. Residual analysis has been performed in order to verify which models fit the data better, opting for a compromise decision given the apparent complexity of residuals plots. As Box states there are no perfect models (but models that work better than others).
%K Calibration
%K Non Linear Calibration
%K Residual Analysis
%K Liquid Chromatography-Tandem Mass Spectrometry
%K Emerging Pollutants
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=74544