%0 Journal Article
%T Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i> Incorporation of Phospholipids
%A Franciane S. Marques
%A Alysson Luiz M. Da Silva
%A Ricardo J. C. Mattoso
%A Roque Aras
%A Rog¨¦rio Jorge B. De Oliveira
%A J¨˛lio C¨¦zar De Abreu Santos
%A Fabio D. Couto
%A Ricardo D. Couto
%J Journal of Biophysical Chemistry
%P 23-38
%@ 2153-0378
%D 2017
%I Scientific Research Publishing
%R 10.4236/jbpc.2017.83003
%X End stage-renal-disease (ESRD) is associated with dyslipidemia and premature
atherosclerosis. The study evaluates the effect of hemodialysis (HD) on
HDL-remodeling between pre- and post-HD. Was conducted a cross-sectional study
with 50 ESRD male patients, undergoing HD at Ana Neri Hospital, Salvador,
Brazil. All individuals were on HD for at least 3 months, into a three<span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">sessions</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">protocol for 3</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">4 hours per week, with a polysulfone low-flow basic-dialyzing-membrane
and unfractionated-heparin. HDL Phospholipid-incorporation was measured by </span><sup><span style=\"font-family:Verdana;\">14</span></sup><span style=\"font-family:Verdana;\">C-PL-scintillation-counting,
expressed as %</span><sup><span style=\"font-family:Verdana;\">14</span></sup><span style=\"font-family:Verdana;\">C-PL/mL/hour. Paraoxonase (PON-1) activity was
measured by spectrophotometry using paraoxon as substrate. Cardiovascular risk
ratios and atherogenic index of plasma were calculated.</span></span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">Total cholesterol, HDL-C and non-HDL-C increased at
post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased
in 30</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">39 and 40</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">-</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">49</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">year</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">(y) at post-HD (p</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">&lt;</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">0.05). LDL-C/apoB
increased in</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">&gt;60</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">y, after HD (p &lt;
%K Hemodialysis
%K Dyslipidemia
%K Cardiovascular Risk Bioindices
%K PLTP
%K PON-1
%K HDL-Remodeling
%K Low-Flow Polysulfone Dialyzing-Membrane
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=78820