%0 Journal Article
%T GnRH Antagonist Protocol: Is It Optimal for All Patients of Different Ages Undergoing <i>In Vitro</i> Fertilization and Embryo Transfer?
%A Weijie Xing
%A Haiyan Lin
%A Qingxue Zhang
%J Advances in Sexual Medicine
%P 153-160
%@ 2164-5205
%D 2017
%I Scientific Research Publishing
%R 10.4236/asm.2017.74012
%X <strong>Background:</strong> To assess the effect of these two protocols in patients of different ages. <strong>Methods:</strong> 1923 <em>in vitro</em> fertilization and embryo transfer (IVF-ET) cycles were divided into two groups: a GnRH-ant protocol group and GnRH-a long protocol group, and then every group were subdivided into four age ranges. The general materials and IVF outcomes were compared. <strong>Results:</strong> The incidence of OHSS fluctuated from 0% to 2.37% with GnRH-ant protocol, which was significantly lower than another (<em>P</em> &lt; 0.05). Of all age ranges, the implantation and clinical pregnancy rates with GnRH-ant protocol were all lower than those with GnRH-a protocol. When the age was less than 35 years old, the CPRs in GnRH-ant protocol group were significantly lower than in another group (45.56% vs. 62.29%, 46.07% vs. 55.59%, respectively; <em>P</em> &lt; 0.05). <strong>Conclusion: </strong>The antagonist protocol should be considered in patients with a high ovarian response (e.g., PCOS patients) to avoid OHSS. Older patients (&gt;35 years) could be treated with the antagonist protocol.
%K GnRH Agonist
%K GnRH Antagonist
%K IVF-ET
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=79249