%0 Journal Article
%T N-Myc Inhibition: Advances in Neuroblastoma Treatment
%A Md Kamrul Hasan
%J CellBio
%P 27-34
%@ 2325-7792
%D 2017
%I Scientific Research Publishing
%R 10.4236/cellbio.2017.63003
%X Neuroblastoma (NBL) is one
of the most common solid tumors and around 15% of cancer mortality in children.
Amplification of the N-Myc proto-oncogene is strongly correlated with
advanced disease and poor clinical outcome in NBL. Recent studies described
that ubiquitin-specific protease 7 (USP7; also known as HAUSP) interacts with
N-Myc, induces deubiquitination and subsequent stabilization of N-Myc that
in-turn potentiates N-Myc
function, and treatment with the HAUSP inhibitor (P22077) blocked such effects.
%K Neuroblastoma
%K N-Myc
%K PI3K/mTOR
%K PARP1
%K PD-L1
%K HAUSP
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=80729