%0 Journal Article
%T Parkinson Kinetic Graph: Are Motor Fluctuations in Parkinson Disease Related with Disease Duration?
%A Esther Berghuis
%A Barbera Van Harten
%A Mirjam Van Kesteren-Biegstraaten
%A Wijnand Rutgers
%A Nicolaas Verwey
%J Advances in Parkinson's Disease
%P 1-6
%@ 2169-9720
%D 2018
%I Scientific Research Publishing
%R 10.4236/apd.2018.71001
%X <div style=\"text-align:justify;\">
	<strong>Introduction</strong>: The Parkinson¡¯s KinetiGraph (PKG) is a digital measurement
system for motor fluctuations (FS). The aim of this study is to investigate
whether FS, measured by the PKG, are associated with disease duration of
Parkinson¡¯s Disease (PD) patients. <strong>Material and Methods</strong>: 172 PD were included.
PKG measurements, clinical data and disease duration were collected.
Patients were categorized in four disease duration categories (0 - 5 years, 6 - 7
years, 8 - 11 years and ¡Ý12 years). Kruskal-Wallis and Mann-Whitney U tests
were used for statistical analysis. <strong>Results</strong>: The mean age of the patients is 69.2
years (SD ¡À 8.13). Disease duration varies between 1 and 28 years. Significant
difference was found between the four disease categories in FS (p = 0.050);
between group 1 - 3, p = 0.005. <strong>Conclusions</strong>: As expected, FS measured by
PKG increase during disease progression in PD. In advanced disease stages,
FS stabilise, indicating that PKG is the most useful in early and moderate
stages of PD.
</div>
%K Late Stage Parkinson Disease
%K Levodopa
%K Disease Duration
%K Fluctuations
%K Dyskinesia
%K Bradykinesia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=82178