%0 Journal Article
%T Early-Onset Alzheimer¡¯s Disease and Metabolic Dysfunction, a Comparative Review
%A Julie Anne Griffith
%A Marie Kelly-Worden
%J Advances in Alzheimer's Disease
%P 1-11
%@ 2169-2467
%D 2018
%I Scientific Research Publishing
%R 10.4236/aad.2018.71001
%X Alzheimer¡¯s disease is quickly becoming one of the most
known diseases in the country due to its devastating effects and lack of
treatment options. Within this lethal disease, there is a smaller group, those
individuals that are diagnosed with early-onset Alzheimer¡¯s disease. It is
understood that these individuals see faster effects of the disease and die
considerably sooner, but it is not understood why. This review compares the
early-onset (EOAD) and late-onset (LOAD) types to try and determine some of the
most blaring differences between the two. The genetic basis linking EOAD and
LOAD has been the apolipoprotein E gene (APOE) to indicate metabolic alteration
with the <span style=\"white-space:nowrap;\">&amp;#949;</span><span style=\"font-family:Verdana;\">4 allele specifically.
The topographical atrophy disparities between EOAD and LOAD supported the more
noticeable cognitive differences between the two Alzheimer¡¯s disease
categories. The faster and wider spread atrophy of EOAD patients correlates
with the difficulty they experience with attention, language, visuo-spatial,
and executive functions. Finally</span><span style=\"font-family:Verdana;\">,</span><span style=\"font-family:Verdana;\"> brain metabolism
differs between both AD subtypes as well, where EOAD indicates the wide spread
damage and metabolic breakdown across more diverse regions of the brain.</span>
%K Alzheimer¡¯s Disease
%K Early-Onset
%K Late-Onset
%K Glucose Metabolism
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=83480