%0 Journal Article
%T Hepatoprotective Effect of Green Tea Extract against Cyclophosphamide Induced Liver Injury in Albino Rats
%A Ali Hassan A. Ali
%J Forensic Medicine and Anatomy Research
%P 11-19
%@ 2327-4107
%D 2018
%I Scientific Research Publishing
%R 10.4236/fmar.2018.62002
%X <strong>Background:</strong> Green tea intake is accompanied with a lower incidence of cardiovascular disease, cancer and neurodegenerative disorders; hence green tea extract has been included as dietary supplement along with other supplements and multivitamins. <strong>Aim of the Work:</strong> Studying the effect of cyclophosphamide administration on the liver of adult male albino rats and the possible protective role of green tea extract. <strong>Material and Methods:</strong> The current study was carried out on 45 adult male albino rats. They were divided into three equal groups (each included 15 rats). Group I (control group) was injected intraperitoneally with normal saline at a dosage of 0.5 mg/kg body weight twice weekly for 9 weeks. Group II was injected intraperitoneally with cyclophosphamide (CP) (150 mg/kg/day) for two weeks. Group III: rats received green tea extracts orally (50 mg/kg/day) for three weeks, and then continued for further two weeks concomitantly with intraperitoneally cyclophosphamide (CP) injected (150 mg/kg/day). <strong>Results:</strong> Rats exposed to cyclophosphamide (CP) showed several histological and histochemical changes in their liver. These changes were improved by using green tea. <strong>Conclusion:</strong> The present work showed that green tea had preventive and therapeutic effect upon livers of albino rats after they were exposed to CP.
%K Green Tea
%K Albino Rats
%K Liver
%K Cyclophosphamide
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=83727