%0 Journal Article
%T A Novel Dihydropyridines C-Glycosylated Compound by Hantzsch Cyclo-Condensation
%A Soheila Sedaghat
%A Shabnam Madjdpour
%J Open Journal of Synthesis Theory and Applications
%P 17-29
%@ 2168-1252
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojsta.2018.72002
%X The Hantzsch synthesis has been used for the preparation of the 1,4-Dihydropyridines compounds with different pharmacophore groups. The use of a designed glycosylated compound in Hantzsch synthesis would lead to a novel Dihydropyridines C-Glycosylated compound. We used the 6-methoxy-2, 2-dimethyltetrahydrofuro [3, 4-d] [1, 3] dioxole-4-carbaldehyde as a glycosylated-based aldehydes. The 4-(3,4-Dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxy-lic acid 3-ethyl ester 5-methyl ester was synthesized. The structure of compounds was determined by NMR spectroscopy, FTIR and mass spectroscopy methods. We synthesized this 1,4-Dihydropyridines compound by ionic liquid under ultrasound irradiation as a green chemistry synthesis.
%K 1
%K 4-Dihydropyridines
%K c-Glycosylated
%K Multi Component Reaction
%K Hantzsch Reaction
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=84170