%0 Journal Article
%T Relationship between Perioperative N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) and Complications in Thoracic Surgery
%A Kantaro Hara
%A Takuma Tsukioka
%A Nobuhiro Izumi
%A Kyukwang Chung
%A Hiroaki Komatsu
%A Michihito Toda
%A Hikaru Miyamoto
%A Satoshi Suzuki
%A Takuya Kimura
%A Toshihiko Shibata
%A Noritoshi Nishiyama
%J Open Journal of Thoracic Surgery
%P 29-36
%@ 2164-3067
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojts.2018.82006
%X <strong><span style=\"font-family:Verdana;\">Background: </span></strong><span style=\"font-family:Verdana;\">In cardiac surgery, the N-terminal pro-brain natriuretic peptide (NT-proBNP) level is reportedly correlated with the onset of postoperative complications. We examined the relationship between the NT-proBNP level and perioperative complications in thoracic surgery and elucidated the significance of NT-proBNP measurement. </span><strong><span style=\"font-family:Verdana;\">Methods: </span></strong><span style=\"font-family:Verdana;\">We evaluated 48 patients excluding hemodialysis patients who underwent lung resection from November 2015 to February 2016. NT-proBNP measurement was performed three times preoperatively on postoperative days 2 and 5. We examined the relationship between clinical background factors such as preoperative comorbidity and the development of postoperative complications. Based on established criteria for surgical complications (Clavien-Dindo classification), grade ¡Ý II was defined as a complications. We classified the patients into two groups (with or without complications) and compared and examined the background factors between the groups. </span><strong><span style=\"font-family:Verdana;\">Results:</span></strong><span style=\"font-family:Verdana;\"> The study included 48 patients (33 male, 15 female) with an average age of 72 years (range, 35 - 86 years). Preoperative comorbidities included cardiovascular disease in five patients, diabetes mellitus in four, and chronic obstructive pulmonary disease in six. The average operation time was 163 (29 - 308) minutes, and the bleeding volume was 30 (10 - 620) ml. Early complications were confirmed in 11 patients, and late complications were confirmed in 7 patients. A high NT-proBNP level on postoperative day 5 was an independent risk factor for late complications. </span><strong><span style=\"font-family:Verdana;\">Conclusion:</span></strong><span style=\"font-family:Verdana;\"> The perioperative NT-proBNP level is considered to be a predictor of complications. Its measurement is useful for predicting postoperative complications, and careful perioperative management is required for patients with high levels.</span>
%K NT-proBNP
%K Perioperative Management
%K Lung Resection
%K Postoperative Complications
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85266