%0 Journal Article
%T Single Nucleotide Polymorphisms (SNPs) of URAT1 (rs7932775) and ABCG2 (rs3825016) on Chronic Kidney Disease Patients with Hyperuricemia
%A Chunqing Li
%A Qiong Tang
%A Hongwei Jiang
%A Jing Wu
%A Junlin Zhang
%A Fenglai Yuan
%A Yuan Du
%A Haochang Du
%J Chinese Medicine
%P 118-125
%@ 2151-1926
%D 2018
%I Scientific Research Publishing
%R 10.4236/cm.2018.93007
%X <b><span style=\"font-family:Verdana;\">Background: </span></b><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">More and more chronic kidney disease (CKD) patients
are accompanied with hyperuricaemia. As is known, hyperuricaemia is an
independent hazard of both cardiovascular diseases (CVD) and chronic kidney
diseases. We aim at identifying Single Nucleotide Polymorphism (SNP) difference
of hURAT1 (rs7932775) and ABCG2 (rs3825016) on CKD patient with hyperuricemia
and/or gout. </span><b><span style=\"font-family:Verdana;\">Methods</span></b></span><b><span style=\"font-family:Verdana;\">:</span></b><b><span style=\"font-family:&quot;\"> </span></b><span style=\"font-family:Verdana;\">All forty-two CKD patients were divided into two
groups</span><span style=\"font-family:Verdana;\">: </span><span style=\"font-family:Verdana;\">hyperuricemia, and control group. 24 hour</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:Verdana;\"> urine sample and serum were prepared for testing
biochemistry parameters. The polymerase chain reaction-restriction fragment
length polymorphism (PCR-RFLP) method is used to anal</span><span style=\"font-family:Verdana;\">yze</span><span style=\"font-family:Verdana;\"> hURAT1 and ABCG2 single nucleotide polymorphisms in
different group</span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">17 patients have CT SNP of hURAT1 (rs7932775) and 13 patients have CT SNP
of ABCG2 (rs3825016) in hyperuricemia group, while only 5 persons and 6 persons
have the same mutations in control group respectively. 7 patients have CT SNP
of both hURAT1 (rs7932775) and ABCG2 (rs3825016) in hyperuricemia group, while
only 2 persons have the same mutations in control group. CT mutation rate</span></span><span style=\"font-family:Verdana;\">s</span><span style=\"font-family:Verdana;\"> of hURAT1</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">(rs7932775) and ABCG2
(rs3825016) in hyperuricemia group were 60.7%</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">(17/28) and 50%</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">(13/28) respectively, higher than that of control
group (35.7%</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">(5/14)
and 42.8%</span><span style=\"font-family:&quot;\">
%K Hyperuricemia
%K Chronic Kidney Disease (CKD)
%K Single Nucleotide Polymorphisms (SNP)
%K Human Urate Transport Protein (Hurat1)
%K ATP Binding Transporter G Super Family (ABCG2)
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=86436