%0 Journal Article
%T Distribution of Genetic Polymorphism in the CCR5 among Caucasians, Asians and Africans: A Systematic Review and Meta-Analysis
%A Beatrice A. Ongadi
%A George Obiero
%A Raphael W. Lihana
%A John N. Kiiru
%J Open Journal of Genetics
%P 54-66
%@ 2162-4461
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojgen.2018.83006
%X <b>Background: </span></b><span style=\"font-family:Verdana;\">Cysteine-Cysteine Chemokine Receptor
5 (CCR5)</span><span style=\"font-family:Verdana;\">,</span><span style=\"font-family:Verdana;\"> also referred to as CD195</span><span style=\"font-family:Verdana;\">,</span><span style=\"font-family:Verdana;\"> is a component of the
mammalian cell membrane and is receptor for chemokines that are activated
during cell damage and inflammations. This receptor is coded by a gene located
in the human chromosome 3. A Mutation on this CCR5 through deletion of 32 base
pairs results into a non-destructive gene CCR5жд32. It enables protection
against HIV infection to its homozygous carriers</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">and slows progression of the disease to heterozygous carriers. </span><b><span style=\"font-family:Verdana;\">Objective</span></b><span style=\"font-family:Verdana;\">:
To systematically review and establish global distribution of CCR5жд32 allele in
HIV-1 infected individuals over the history of the epidemic and compare regions
inhabited by Caucasians, Asians and Africans. </span><b><span style=\"font-family:Verdana;\">Methodology: </span></b><span style=\"font-family:Verdana;\">This
meta-analysis comprised of published papers with over 10,000 individuals from
whom CCR5-Delta</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">32 allele was successfully
genotyped and recorded. The study review period was from 1984 to 2017. The
search targeted online sources such as Hinari specifically PubMed Central,
Google scholar, Science Direct, Research4Life, National Center for
Biotechnology Information (NCBI), OVID databases, AIDS Journal and Google. The
searches were not limited to a particular publication language or study design
but excluded letters of correspondence and conference presentations. Search
strategy using key words from a combination of Medical Subject Heading (MeSH)
and free text including terms related to CCR5, CCR5жд32 and HIV were performed
in Medical Literature Analysis and Retrieval System Online (MEDLINE) through
Ovid</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">Open</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">Access. Additional studies were identified by perusing the reference list
of relevant and included articles. The review considered studies conducted
among general population, both HIV
%K CCR5
%K CCR5жд32
%K HIV
%K Genetic Polymorphism
%K Allele Frequency
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87302