%0 Journal Article
%T DNA-Like Duplex Structures Derived from Chemistry Based on 2กฏ-Deoxy-Cytidine: A New Model for Base-Specific Inhibition of G and C on DNA and RNA Level
%A Henk M. Buck
%J Journal of Biophysical Chemistry
%P 23-40
%@ 2153-0378
%D 2018
%I Scientific Research Publishing
%R 10.4236/jbpc.2018.93003
%X The new epigenetic elements 5-hydroxymethyl-dC, 5-formyl-dC, and 5-car<span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">- </span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">boxy-dC may be considered as intermediates of an
active demethylation process. A comprehensive mechanistic model</span></span></span></span><span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">is given for the C-C bond cleavage focused on the
chemistry within the DNA duplex structure. In addition we register spin-off
chemistry of this process in evaluating new</span></span></span></span><span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">duplex systems closely related to natural DNA and
RNA</span></span></span></span><span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">concerning their hydrogen-bond symmetrization. A
model is</span></span></span></span><span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">composed for a base-specific inhibition of G and C
on the DNA and RNA level. C-G combinations are of general importance in
controlling the dynamics of gene expression. In some way the suggested model
systems are related to antisense oligonucleotides (ASOs).</span></span></span></span>
%K Active Demethylation
%K DNA Catalysis
%K Symmetry Elements
%K (Anti)Parallel Modified DNA and RNA
%K Inhibition of Genetic Information
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=89676