%0 Journal Article
%T Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians
%A Garc¨ªa-L¨®pez Carlos Alberto
%A Alc¨¢zar-Casar¨ªn Emmanuel
%A Ynga-Durand Mario Alberto
%A Alonso-Bello C¨¦sar Daniel
%A Lozano-Patino Fernando
%A Vargas-Camano Mar¨ªa Eugenia
%A Espinosa-Padilla Sara Elva
%A Gonz¨¢lez-Serrano Maria Edith
%A Castrej¨®n-V¨¢zquez Mar¨ªa Isabel
%J Open Access Library Journal
%V 6
%N 5
%P 1-15
%@ 2333-9721
%D 2019
%I Open Access Library
%R 10.4236/oalib.1105419
%X
Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in order to provide a resource that will help non-immunological clinicians to recognize and appropriately refer to these cases. Materials and Methods: Review of the literature with scientific articles indexed in English and Spanish. We consulted Pubmed database with the keywords: primary immunodeficiencies and severe combined immu-nodeficiencies. The limit of time was 5 years and only review papers. Re-sults: The search in the database results in 68 papers and we analyzed 35 articles because the objective of the review was Severe Combined Immu-nodeficiencies. Discussion: Persistent lymphopenia (usually <2500 xmm3) detected in blood cell cytometry that accompanies severe, recurrent infec-tions, autoimmune manifestations, atopy and cancer may suggest severe combined immunodeficiency. Causes of secondary immunodeficiency such as HIV should be ruled out. Conclusions: Persistent lymphopenia can be associated with severe combined immunodeficiency. The study should be extended in these cases by a specialist or refer the patient to a referral center for a complete evaluation.
%K Primary Immunodeficiencies
%K Immunodeficiency
%K Approach
%K Lymphopenia
%U http://www.oalib.com/paper/5361615