%0 Journal Article
%T Thiosemicarbazones Synthesized from Acetophenones: Tautomerism, Spectrometric Data, Reactivity and Theoretical Calculations
%A Bel¨¦n Gastaca
%A Hern¨¢n Rub¨¦n S¨¢nchez
%A Fiorella Menestrina
%A Maricel Caputo
%A Mar¨ªa de las Mercedes Schiavoni
%A Jorge Javier Pedro Furlong
%J International Journal of Analytical Mass Spectrometry and Chromatography
%P 19-34
%@ 2332-1776
%D 2019
%I Scientific Research Publishing
%R 10.4236/ijamsc.2019.72003
%X Tautomeric forms of Thiosemicarbazones have been investigated by spectrometric methods, their chemical reactivity and theoretical calculations of the relative tautomers stabilities. The mass spectral fragmentation of thiosemicarbazones synthesized from acetophenones has been studied by CG/MS. The analysis of the corresponding spectra shows not only the regular fragmentation mechanisms but homolytic ruptures from even-electron species. 1H NMR spectra exhibit signals for the most intense open thioketo tautomeric structure, although when using TFA a ring structure is observed in the corresponding tautomeric equilibrium. Density Functional Theory calculations (DFT) also provide evidence to support the experimental observations by GC-MS and 1H NMR. Methylation reactions give support to the occurrence of the thioenol tautomeric form which would be the second most abundant according to the Density Functional Theoretical calculations.
%K Thiosemicarbazones
%K Tautomerism
%K MS
%K NMR
%K Theoretical Calculations
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=94074