%0 Journal Article
%T Structural Change in Dimyristoyl Phosphatidyl Choline (DMPC) Molecule Alkyl Chains on the Addition of Cholesterol to DMPC Monolayer: Specific Addition Effect of Cholesterol
%A Daiki Ito
%A Takanari Ikeda
%A Keijiro Taga
%A Yasushi Yamamoto
%A Zameer Shervani
%A Masato Yamamoto
%J Journal of Biophysical Chemistry
%P 15-29
%@ 2153-0378
%D 2019
%I Scientific Research Publishing
%R 10.4236/jbpc.2019.102002
%X We have investigated the morphology of dimyristoyl phosphatidyl choline
(DM<span>PC)¡ªcholesterol mixed monolayer formed on
the water surface by drop</span><span>ping method using surface tension measurement
(STm), Brewster angle microscopy (BAM), and infrared external reflection
spectroscopy (IERS). STm results showed negative deviation of the limiting
molecular area (</span><i><span>A</span></i><sub><span>0</span></sub><span>) of cholesterol
occurred when cholesterol was added to the DMPC monolayer. BAM images showed
the expandable DMPC monolayer changed to the condensed rigid monolayer at more
than cholesterol mole fraction (</span><i><span>x</span><sub><span>Chol</span></sub></i><span>)
0.4. IERS recordings showed that the addition of cholesterol at </span><i><span>x</span><sub><span>Chol</span></sub></i><span> = 0.4 occurred structural
change from </span><i><span>gauche</span></i><span>- to </span><i><span>trans</span></i><span>-</span><span><span><span> </span></span></span><span><span><span><span>conformation
of two DMPC molecule </span><span>alkyl chains. From these
results, it is found that cholesterol molecule has sp</span><span>ecific properties
that cause structural transition of DMPC molecule alkyl chains.</span></span></span></span>
%K Dimyristoyl Phosphatidyl Choline (DMPC)
%K Cholesterol
%K Surface Tension Measurement (STm)
%K Brewster Angle Microscopy (BAM)
%K Infrared External Reflection Microscopy (IERS)
%K Structural Transition
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=96862