%0 Journal Article
%T 浅析中国防控非洲猪瘟药物最新进展<br>A Brief Analysis of China’s Recent Progress in Drug Prevention and Control of African Swine Fever
%A 肖和良
%J Asian Case Reports in Veterinary Medicine
%P 61-66
%@ 2169-8902
%D 2019
%I Hans Publishing
%R 10.12677/ACRPVM.2019.84009
%X <div style=\"text-align:justify;\">
	<span style=\"font-size:14px;\">中国开展了对非洲猪瘟病毒基础理论研究和防控非洲猪瘟药物研制。研究表明：非洲猪瘟病毒，为双链DNA结构、24个基因型、病毒编码150多种蛋白，基因组由两层衣壳和两层外膜保护，衣壳主要由病毒编码蛋白p72构成。研究出非洲猪瘟病毒的DNA连接酶(AsfvDNAL)结构和p72蛋白折叠结构，正确折叠的p72蛋白以及确定其高分辨率结构有助于开发靶向病毒衣壳组装的药物。中国对非洲猪瘟病毒基础理论研究处于世界先进水平，为研制防治非洲猪瘟药物打下了坚实基础。针对性研究非洲猪瘟病毒DNA修复通路蛋白，抑制和阻断非洲猪瘟病毒复制，抑制II型拓扑异构酶药物，或直接杀灭病毒和预防药物作用的药物。本文介绍的海洋生物、病毒DNA修复通路蛋白药物、伊曲康唑、25-羟基胆固醇盐酸、恩诺沙星、刺五加、银蟾散等防治非洲猪瘟药物，对非洲猪瘟病毒防治针对性强，作用机理明确，代表了中国传统中医药与现代兽药制药技术结合的方向。展望中国防控非洲猪瘟的药物防治效果达85%以上，高的可达92%，在1年内形成防控非洲猪瘟药物产品，将发挥防治非洲猪瘟巨大作用。<br />
China has carried out research on the basic theory of Africa swine fever virus and the development of drugs for the prevention and control of Africa swine fever. The study showed that the African swine fever virus is a double-stranded DNA structure, 24 genotypes, and more than 150 proteins encoded by the virus. The genome is protected by two capsids and two outer membranes. The capsid is mainly composed of viral coding proteins p72. The study of the DNA ligase (Asfv DNAL) structure and p72 protein folding structure of the African swine fever virus, the correct folding of the p72 protein, and the determination of its high-resolution structure help to develop drugs that target viral capsid assembly. In China the research on the basic theory of African swine fever virus is at an advanced level in the world, which has laid a solid foundation for the development and prevention of African swine fever drugs. We have targeted research on African swine fever virus DNA repair pathway proteins, inhibition and blocking of African swine fever virus replication, inhibition of type II topoisomerase drugs, or drugs that directly kill viruses and prevent drug effects. In this paper, marine organisms, viral DNA repair pathway protein drugs, Itraconazole, 25-hydroxycholesterol hydrochloric acid, Ennuoshaxing, acanthopanax, silver wolfberry powder and other drugs, the prevention and treatment of African swine fever virus are highly targeted for the prevention and treatment of African swine fever, and the mechanism of action is clear. It represents the direction of combining traditional Chinese medicine with modern veterinary pharmaceutical technology. It is expected that the drug control effect of preventing and controlling swine fever in Africa will reach more than 85%, and it will reach a high of 92%. Within one year, a drug product for the prevention and control of Africa swine fever will be formed, and it will play a huge role in preventing and controlling Africa swine fever.</span> 
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%K 非洲猪瘟，防控药物，海洋生物药物，伊曲康唑，银蟾散，病毒DNA修复通路蛋白药物，靶向病毒衣壳组装药物，最新进展<br>African Swine Fever
%K Drug Control
%K Marine Drug
%K Itraconazole
%K Silver Toad Powder
%K Viral DNA Repair Pathway Protein Drug
%K Targeting Virus Capsid Assembly Drug
%K Latest Progress
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=32426