%0 Journal Article
%T 亚磷酸酯催化的亚胺与丙烯酸甲酯的氮杂Baylis-Hillman反应研究<br>Phosphite Catalyzed Aza-Baylis-Hillman Reaction of Imines and Methyl Acrylates
%A 贾俊
%A 姚其波
%A 陶京朝
%A 王兴旺
%J Studies in Synthetic Chemistry
%P 33-41
%@ 2332-7960
%D 2020
%I Hans Publishing
%R 10.12677/SSC.2020.81004
%X 本文以一系列亚磷酸酯为催化剂，对催化芳香醛亚胺与丙烯酸甲酯的氮杂Baylis-Hillman反应进行了系统研究。经过对该反应的溶剂、反应温度、底物浓度、催化剂进行了筛选和优化，我们发现亚磷酸二乙酯和1,4-二氮杂二环[2.2.2]辛烷(DABCO)能有效催化该反应。最后对一系列底物进行测试，所有反应能以中等到良好的收率得到α-亚甲基β-磺酰胺基丙烯酸酯产物。<br />
The aza-Bayllis-Hillman reactions of imines and methyl acrylate catalyzed by achiral phosphite were studied. The reaction conditions, such as solvent, temperature, concentration, catalysts, and substrates were screened. The target products of α-methylene--sulfonamido acrylates were obtained with 25% - 78% yield.<br />
%K 氮杂Baylis-Hillman反应，亚磷酸酯，亚胺，丙烯酸甲酯，α-亚甲基β-磺酰胺基丙烯酸酯<br>aza-Bayllis-Hillman Reaction
%K Phosphite
%K Imine
%K Methyl Acrylates
%K α-Methylene--Sulfonamido Acrylates
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=34864