%0 Journal Article
%T Risks associated with fertility preservation for women with sickle cell anemia - Fertility and Sterility
%A Jacqueline Y. Maher
%A Jennie Y. Law
%A Lydia H. Pecker
%A Mary Catherine Beach
%A Mindy S. Christianson
%A Sophie Lanzkron
%J Fertility and Sterility
%D 2018
%R https://doi.org/10.1016/j.fertnstert.2018.05.016
%X To highlight the risk of complications among women with sickle cell anemia (SCA) receiving fertility preservation treatment (FPT) before hematopoietic stem cell transplant (HSCT). Single-center case series. Academic fertility center. Women aged 15每32 years with SCA undergoing FPT before HSCT. Retrospective, systematic review. FPT modality, SCA complications during FPT. Over an 8-year period (2009每2017), seven women with SCA ages 15每32 years (mean 28.5 years) underwent FPT with embryo cryopreservation (n = 1), oocyte cryopreservation (n = 4), and ovarian tissue cryopreservation (n = 2). The five women subjects who underwent oocyte or embryo cryopreservation were treated with an antagonist controlled ovarian hyperstimulation protocol and individualized gonadotropin dosing. The trigger medications included leuprolide acetate (n = 2), and human chorionic gonadotropin (n = 3). Most patients (n = 5) received a disease-modifying therapy for SCA (hydroxyurea or chronic transfusions) before FPT. Three patients experienced periprocedural SCA complications that included life-threatening respiratory failure, painful crisis requiring interruption of a stimulation cycle, and severe postharvest painful crisis. Women with SCA may choose to undergo diverse FPT strategies before HSCT and are at risk for serious SCA-related complications. Evidence-based strategies to mitigate SCA-related morbidity and to optimize fertility preservation outcomes are needed. Riesgos asociados a la preservaci車n de fertilidad en mujeres con anemia de c谷lulas falciformes. Subrayar el riesgo de complicaciones entre las mujeres con anemia de c谷lulas falciformes (SCA) que realizan preservaci車n de fertilidad (FPT) antes de someterse a un transplante de c谷lulas madre hematopoy谷ticas (HSCT). Serie de casos de un centro 迆nico. Centro de fertilidad universitario. Mujeres de edades comprendidas entre 15 y 32 aˋos con SCA sometidas a FPT antes de HSCT. Revisi車n sistem芍tica retrospectiva. Modalidad de FPT, complicaciones de la SCA durante la FPT. En un periodo de 8 aˋos (2009-2017), siete mujeres con SCA de edades comprendidas entre 15 y 32 aˋos (media 28,5 aˋos) realizaron FPT con criopreservaci車n de embriones (n=1), criopreservaci車n de ovocitos (n=4) y criopreservaci車n de tejido ov芍rico (n=2). Las cinco mujeres que realizaron criopreservaci車n de ovocitos o embriones siguieron un protocolo de hiperestimulaci車n ov芍rica controlada con antagonistas y dosis individualizadas de gonadotrofinas. La maduraci車n ov芍rica se indujo con acetato de leuprolide (n=2) y gonadotrofina cori車nica humana (n=3). La mayor赤a
%U https://www.fertstert.org/article/S0015-0282(18)30417-5/fulltext