%0 Journal Article
%T Treatment of vaginal agenesis in Mayer-Rokitansky-K邦ster-Hauser syndrome in Denmark: a nationwide comparative study of anatomical outcome and complications - Fertility and Sterility
%A Anne-Mette Bay Bjˋrn
%A Birgitta Trolle
%A Laura Krogh Jˋrgensen
%A Michael Bjˋrn Petersen
%A Morten Herlin
%J Fertility and Sterility
%D 2018
%R https://doi.org/10.1016/j.fertnstert.2018.05.015
%X To compare the long-term anatomical outcome and complications in treatments of vaginal agenesis in Mayer-Rokitansky-K邦ster-Hauser (MRKH) syndrome. A historical comparative follow-up study using medical chart reviews. Public hospitals. A nationwide cohort of patients diagnosed with MRKH syndrome (n = 168). McIndoe vaginoplasty (n = 54), self-dilation (n = 60), coital dilation (n = 20), Baldwin vaginoplasty (n = 4), Williams vaginoplasty (n = 3), Davydov vaginoplasty (n = 2), or no treatment (n = 29). Mean vaginal depth at follow-up, anatomical treatment success rates at levels of ≡6 cm, ≡7 cm, and ≡8 cm, complications, and resurgery. Mean vaginal depths were 7.4 cm (95% confidence interval [CI] 6.8每8.1 cm), 7.3 cm (95% CI 6.7每7.9 cm), and 8.7 cm (95% CI 7.9每9.5 cm) at follow-up in patients treated by McIndoe vaginoplasty, self-dilation, and coital dilation, respectively. Overall complication rates in the three groups were 35/54 (65%), 21/52 (35%), and 1/20 (5%), respectively. Eighteen (33%) of the patients who underwent McIndoe vaginoplasty needed resurgery. Our findings support the current recommendations of dilation therapy as the first-line treatment of vaginal agenesis and emphasize the relevance of coital dilation in patients able to regularly engage in coital activity. However, further studies of functional outcome and patient satisfaction are needed. Tratamiento de la agenesia vaginal en el s赤ndrome de Mayer-Rokitansky-K邦ster-Hauser en Dinamarca: un estudio comparativo a escala nacional del resultado anat車mico y las complicaciones. Comparar el resultado anat車mico y complicaciones a largo plazo en tratamientos de agenesia vaginal en s赤ndrome de Mayer-Rokitansky-K邦ster-Hauser (MRKH). Un estudio de seguimiento hist車rico comparativo usando revisiones de historias m谷dicas. Hospitales p迆blicos. Una cohorte de pacientes a escala nacional diagnosticadas de MRKH (n = 168). Vaginoplastia de McIndoe (n = 54), auto-dilataci車n (n = 60), dilataci車n coital (n = 20), vaginoplastia de Baldwin (n = 4), vaginoplastia de Williams (n = 3), vaginoplastia de Davydov (n = 2) o sin tratamiento (n = 29). Profundidad vaginal media en el seguimiento, tasas de 谷xito terap谷utico anat車mico con niveles de ≡ 6 cm, ≡ 7 cm, y ≡ 8 cm, complicaciones y reintervenci車n quir迆rgica. Las profundidades vaginales medias fueron 7,4 cm (Intervalo de confianza [CI]del 95% 6,8-8,1 cm), 7,3 cm (95% CI 6,7-7,9 cm), y 8,7 cm (95% CI 7,9-9,5 cm) en el seguimiento de pacientes tratadas con vaginoplastia de McIndoe, auto-dilataci車n, y dilataci車n coital, respectivamente. Las tasas de complicaciones
%U https://www.fertstert.org/article/S0015-0282(18)30416-3/fulltext