%0 Journal Article
%T Vitamin D levels are not associated with ovarian reserve in a group of infertile women with a high prevalance of diminished ovarian reserve - Fertility and Sterility
%A Alice J. Shapiro
%A David H. Barad
%A Norbert Gleicher
%A Sarah K. Darmon
%A Vitaly A. Kushnir
%J Fertility and Sterility
%D 2018
%R https://doi.org/10.1016/j.fertnstert.2018.05.005
%X To determine whether a relationship exists between vitamin D (25OH-D) levels and ovarian reserve parameters (antim¨¹llerian hormone [AMH] and FSH levels) in a large cohort of infertile women with a high prevalence of diminished ovarian reserve. Retrospective cohort study. Academically affiliated private fertility center. A total of 457 infertile women 21¨C50 years of age who had baseline hormone measurements. None. Statistical analyses to determine whether a relationship exists between AMH, FSH, and serum 25OH-D levels. As defined by 25OH-D <20.0 ng/mL, 74/457 patients (16.2%) had vitamin D deficiency. AMH and FSH levels did not vary between women with vitamin D deficiency and those with normal levels (0.8 ¡À 3.0 vs. 0.5 ¡À 1.6 ng/mL [P=.18] and 9.4 ¡À 7.2 vs. 9.2 ¡À 9.5 mIU/mL [P=.54], respectively). Multivariate linear regression analysis of log-transformed AMH and FSH with 25OH-D levels adjusted for age, body mass index, and seasonal variation confirmed lack of association. Receiver operating characteristic (ROC) analysis to determine if 25OH-D levels are predictive of AMH showed areas under the ROC curves (AUCs) for women <38 years of age to be 0.501, 0.554, and 0.511 for AMH threshold values of 0.5 ng/mL, 1.0 ng/mL, and 5.0 ng/mL, respectively. For women ¡Ý38 years respective AUC values were 0.549, 0.545, and 0.557 ng/mL. Vitamin D levels were not associated with ovarian reserve in a large group of infertile women with a high prevalence of diminished ovarian reserve. Previously reported vitamin D¨Cassociated outcomes in infertility patients may, therefore, be mediated by factors other than ovarian reserve. Los niveles de vitamina D no se asocian con la reserva ov¨¢rica en un grupo de mujeres inf¨¦rtiles con una alta prevalencia de baja reserva ov¨¢rica Determinar si existe una relaci¨®n entre los niveles de vitamina D (25OH-D) y los par¨¢metros de reserva ov¨¢rica (hormona anti-m¨¹lleriana (AMH) y FSH) en una amplia cohorte de mujeres inf¨¦rtiles con una alta prevalencia de baja reserva ov¨¢rica. Estudio retrospectivo de cohorte. Centros privados de fertilidad acad¨¦micamente asociados. Un total de 457 mujeres inf¨¦rtiles con edad entre 25-50 a£¿os a las que se les realiz¨® una determinaci¨®n basal hormonal de hormonas. Ninguna. An¨¢lisis estad¨ªstico para determinar si existe una relaci¨®n entre los niveles s¨¦ricos de AMH, FSH y 25OH-D. 74 de 457 pacientes (16,2%) tuvieron un d¨¦ficit de vitamina D, definido por un nivel s¨¦rico de 25OH-D <20 ng/mL. Los niveles s¨¦ricos de AMH y FSH no han variado entre las mujeres con d¨¦ficit de vitamina D y aquellas con valores normales
%U https://www.fertstert.org/article/S0015-0282(18)30406-0/fulltext