%0 Journal Article
%T Endometrial scratch injury for women with one or more previous failed embryo transfers: a systematic review and meta-analysis of randomized controlled trials - Fertility and Sterility
%A Aless
%A Amerigo Vitagliano
%A Attilio Di Spiezio Sardo
%A Fabrizio Sapia
%A Gabriele Saccone
%A Gaetano Valenti
%A Guido Ambrosini
%A Mija Blaganje
%A Mohan S. Kamath
%A ra Andrisani
%J Fertility and Sterility
%D 2018
%R https://doi.org/10.1016/j.fertnstert.2018.04.040
%X To investigate endometrial scratch injury (ESI) as an intervention to improve IVF outcome in women with a history of ET failure. Systematic review and meta-analysis. Not applicable. Infertile women undergoing IVF after one or more failed ET. We included all randomized controlled trials of women undergoing IVF after one or more failed ET, where the intervention group received ESI and controls received placebo or no intervention. Pooled results were expressed as relative risk (RR) with a 95% confidence interval (95% CI). The review protocol was registered in PROSPERO before starting the data extraction (CRD42017082777). Live birth rate (LBR), clinical pregnancy rate (PR), multiple PR, miscarriage rate, ectopic pregnancy (EP) PR. Ten studies were included (1,468 participants). The intervention group showed higher LBR (RR 1.38, 95% CI 1.05每1.80) and clinical PR (RR 1.34, 95% CI 1.07每1.67) in comparison to controls, without difference in terms of multiple PR, miscarriage rate, and EP PR. Double luteal ESI with pipelle was associated with the greatest effect on LBR (RR 1.54, 95% CI 1.10每2.16) and clinical PR (RR 1.30, 95% CI 1.03每1.65). The ESI was beneficial for patients with two or more previous ET failure, but not for women with a single previous failed ET. No effect was found in women undergoing frozen-thawed ET cycles. The ESI may improve IVF success in patients with two or more previous ET failures undergoing fresh ET. The ESI timing and technique seem to play a crucial role in determining its effect on embryo implantation. Lesi車n por rascado endometrial para mujeres con uno o m芍s fracasos previos en transferencias de embriones: Una revisi車n sistem芍tica y meta-an芍lisis de los estudios controlados aleatorizados Investigar la lesi車n por rascado endometrial (ESI) como una intervenci車n para mejorar el resultado de FIV en mujeres con historia de fracaso en transferencias de embriones. Revisi車n sistem芍tica y meta-an芍lisis. No aplica. Mujeres est谷riles sometidas a FIV despu谷s de uno o m芍s fracasos previos en transferencias de embriones. Se incluyen todos los estudios controlados aleatorizados de mujeres sometidas a FIV despu谷s de uno o m芍s fracasos en transferencias de embriones, donde al grupo con intervenci車n se le practic車 ESI y los controles recibieron placebo o ninguna intervenci車n. Los resultados agrupados se expresaron como riesgo relativo (RR) con un intervalo de confianza del 95% (95% CI). El protocolo de revisi車n fue registrado en PROSPERO antes de iniciar la extracci車n de los datos (CRD42017082777). Tasa de nacido vivo (LBR), tasa de gestaci車n
%U https://www.fertstert.org/article/S0015-0282(18)30394-7/fulltext