%0 Journal Article
%T Factors Associated With the Development of Diabetes Mellitus
Following a First Episode of Acute Pancreatitis | Insight Medical Publishing
%A Alon Grossman
%A Genady Drozdinsky
%A Shachaf Shiber
%J January 2019
%D 2018
%X Aim To determine the prevalence and risk factors of new-onset diabetes mellitus in patients after a first episode of acute pancreatitis. Methods A retrospective study design was used. Patients diagnosed with a first episode of acute pancreatitis in the emergency department of a tertiary medical center in 2010-2016 were followed for the occurrence of diabetes mellitus. Clinical data were collected from the medical records and compared between patients with and without a subsequent diagnosis of diabetes. Results Of 500 patients who presented with a first episode of acute pancreatitis during the study period, 41 (8.2%) were subsequently diagnosed with diabetes and 29 (5.6%), with pre-diabetes, and 312 (62.4%) had normal glucose levels; the remainder had pre-existing diabetes. Mean duration of follow-up was 6.7¡À3.1 years, and mean interval between diagnoses was 1.46¡À1.4 years. Compared to the patients with normal glucose levels, the diabetes group was characterized by older age (64¡À17 years vs. 54¡À21 years, p<0.01) and higher blood pressure values (systolic: 147¡À21 mmHg vs.131¡À23 mmHg, p<0.01; diastolic: 83¡À15 mmHg vs.74¡À13 mmHg, p=0.013) at presentation to the emergency department, higher score on the Bedside Index for Severity in Acute Pancreatitis (BISAP; 1.22¡À0.85 vs. 0.88¡À0.87, p=0.02), and higher rate of non-biliary pancreatitis (45% vs. 26.8%, p=0.02). Conclusions Risk factors for the development of diabetes after a first episode of acute pancreatitis include high blood pressure, high BISAP score, and non-biliary etiology. These findings in patients who present to the emergency department with acute pancreatitis should alert the clinician to the need for close monitoring for diabetes.
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