%0 Journal Article
%T Opening windows for bone remodeling through a SLIT
%A Jameel Iqbal
%A Mone Zaidi
%A Se-Min Kim
%A Tony Yuen
%J The Journal of Clinical Investigation
%D 2018
%R 10.1172/JCI120325
%X Bone formation and resorption are tightly coupled, and dysfunction of either process leads to bone diseases, such as osteoporosis. Bone-forming agents have been explored clinically to increase bone density; however, long-term efficacy of these strategies is limited due to the accompanying increase in resorption in response to increased bone formation. Axonal guidance molecules have recently been shown to regulate formation-resorption coupling and thus have the potential for osteoporosis therapy. In this issue of the JCI, Kim et al. demonstrate that osteoclast-secreted SLIT3 influences bone formation and resorption by promoting osteoblast migration and suppressing osteoclast differentiation. Activation of SLIT3/ROBO signaling in ovariectomized mice increased bone mass, suggesting that SLIT3 should be further explored as a therapeutic target
%U https://www.jci.org/articles/view/120325