%0 Journal Article
%T CD4+ Cell Count, Lipid And Lipoprotein Levels In Hiv Patients On Drug Treatment SciDoc Publishers | Open Access | Science Journals | Media Partners
%A Adepeju Akinlawon A
%A Adetoro Taofik A
%A Adeyeye Adetunji D
%A Muhibi Musa A
%A Olaoye Jelili A
%A Olisekodiaka Japhet M
%A Onifade Abdufatah A
%A Oyenike Musiliu A
%A UGWU Prince I
%A Adedokun Kamoru A
%J HIV/AIDS and Research (IJHR)
%D 2018
%R http://dx.doi.org/10.19070/2379-1586-1700029
%X Abstract Background: Previous reports showed lack of consensus on the possible etiology of coronary artery disease (CAD) between HIV-treatment with highly active antiretroviral therapy (HAART) and HIV-infection in particular. The aim of this study was to find out correlations of HIV-treatment and HIV-infection with CAD risk. Method: One hundred and twenty (120) participants involving HIV-patients on treatment (n = 40), treatment-na£¿ve (n = 40) and equal number of age- and sex-matched controls were enrolled. The total cholesterol, triglycerides and lipoprotein (HDL-C) were analyzed using spectrophotometry. The LDL-C was calculated using Friedewald equation, TC/HDL-C and LDL-C/HDL-C ratios were also calculated. The CD4+ cell count was determined using flow cytometry. Result: The mean plasma total cholesterol levels in patients¡¯ groups on treatment and treatment-na£¿ve were significantly reduced when compared with controls, but the mean triglyceride levels for both treatment and the treatment-na£¿ve groups were significantly increased when compared with controls. However, HDL-C and LDL-C values for patients on HAART and the treatment-naive were significantly reduced when compared with controls respectively. The CAD risk predictors, LDL-c and TC/HDL-C ratio, were significantly increased in patients on HAART when compared with the treatment-naive. The mean CD4+ cell count in treatment-naive was significantly lowered against both groups for treatment and controls. Conclusion: In this present study, abnormal lipid profile was associated with both HIV-infection and HAART-treatment. However, TC/HDL-C ratio, the strong predictor of CAD events in metabolic disorder was markedly high in HAARTtreatment and the associated difference may threaten higher risk for cardiovascular disease (CVD) during treatment
%K n/a
%U https://scidoc.org/IJHR-2379-1586-04-102.php