%0 Journal Article
%T Differentiation of Neural Progenitor Cells from Pluripotent Stem Cells in Artificial Niches SciDoc Publishers | Open Access | Science Journals | Media Partners
%A Sebastien Sart
%A Yan Li
%A Yuanwei Yan
%J Stem Cell Research and Transplantation (IJST)
%D 2018
%R http://dx.doi.org/10.19070/2328-3548-130004
%X Abstract Neural progenitor cells (NPCs) derived from pluripotent stem cells (PSCs) provide a promising cell source for disease modeling, drug screening, and tissue engineering. To fulfill the potentials of PSC-derived NPCs, a series of fundamental issues, especiallythe effects of stem cell niches, need to be elucidated to gain a precise control over stem cell response. This article discussed several important niche factors that affect NPC differentiation from PSCs: 1) seedingdensity to represent cell-cell interactions; 2) the extracellular matrix (ECM)-bound growth factors to present cell-growth factor interactions; and 3) the substrate stiffness to represent cell-matrix interactions. Understanding the effects of these factors will better recreate the stem cell niche to promote neural differentiation from PSCs
%K n/a
%U https://scidoc.org/IJST-2328-3548-01-401.php