%0 Journal Article
%T Simulated Evaluation of Drug-Impaired Psychomotor Performance
%A Richmond R
%J Clinical Pharmacology & Toxicology (IJCPT)
%D 2018
%R http://dx.doi.org/10.19070/2167-910X-1400021
%X The purpose of this placebo-controlled, randomized-crossover study was to evaluate a computer-based divided-attention task as a method for measure impaired human psychomotor performance. The ability of the divided-attention task to detect and differentiate was evaluated using single oral doses of placebo, caffeine and diphenhydramine. Ten healthy men were the subjects of the study. Subject performance on divided-attention was compared with tests of short-term memory and a set of visual analogue scales. The study also assessed potential learning and boredom effects associated with the testing procedures. The results indicate a divided-attention task can detect and differentiate effects of diphenhydramine from those of caffeine and placebo; however, it cannot differentiate effects of caffeine at the doses utilized from that of placebo. Visual analogue scale results corroborated these findings. Observations show that the short-term memory test was not sensitive to the effects of study medication. While the results observed with this convenient, computer-based divided-attention task are promising, additional studies need to be conducted with other classes of CNS-active drugs and over a range of doses
%K n/a
%U https://scidoc.org/IJCPT-2167-910X-03-201.php