%0 Journal Article
%T THYROID DYSFUNCTION AND BLOOD PRESSURE COMPONENTS: MULTIVARIATE STATISTICAL ASSOCIATIONS
%A GROOTVELD M.
%A MAJELLA L.J.
%A MEENAKSHISUNDARAM R.
%A NIRUBHANBHARATHY R.V.
%A NITHYA E.
%A THIRUMALAIKOLUNDUSUBRAMANIAN P.
%J BioInfo Publication
%D 2014
%X Background: Although thyroid dysfunctions exert significant effects on blood pressure (BP), published literature available has revealed con-tradictory data. Objectives: To explore the inter-relationships between selected thyroid dysfunctional status (hyper and hypothyroid conditions) and estab-lished biomarkers [thyroid stimulating hormone (TSH) and thyroxine (T4)]; and BP components [specifically Systolic BP (SBP), Diastolic BP (DBP), and Mean Arterial Pressure (MAP), and uniquely SBP:DBP ratio]. Materials and Methods: We followed rigid criteria in order to select adults with hyperthyroidism (n=71) and hypothyroidism (n=300), together with healthy age-matched controls (n =300), and applied a series of statistical analysis strategies to the datasets acquired. Results: Univariate statistical analyses of the SBP:DBP ratio by ANOVA and ANCOVA revealed that its mean value was significantly greater in hyperthyroid patients than those of healthy control and hypothyroid subjects (p£¿0.0001). Body mass index (BMI) was significantly elevated in hypothyroid patients over those of healthy control and hyperthyroid subjects (p£¿0.0001); healthy controls had a significantly greater BMI value than that of hyperthyroid patients (p£¿0.0001). Multivariate (MV) analysis [redundancy analysis (RDA), canonical correlation analysis (CCorA), and principal component analysis (PCA)] demonstrated powerful relationships between all blood pressure components and thyroid disease classifications, together with their biomarker indices and further patient-related parameters. Conclusions: Since thyroid dysfunctional status is associated with elevated BP, and increasing BP is positively-correlated with elevated se-rum thyroid biomarkers, hyper and hypothyroid disorders should be recognized and treated early in order to avoid critical hazards presented by high BP
%U https://bioinfopublication.org/viewhtml.php?artid=BIA0002260